Cyclin-dependent kinase 5 (CDK5)

About Cyclin-dependent kinase 5

Cyclin-dependent kinase 5 (CDK5) is a protein from Homo sapiens identified by UniProt accession Q00535, 292 residues long. MolForge cross-references it against 0 known binders and 359 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 5
UniProt accession	Q00535
Gene	CDK5
Organism	Homo sapiens
Length	292 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00535-F1	alphafold	PREDICTED	91.56	—

Amino-acid sequence (292 residues)

MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards