Transcriptional activator protein Pur-alpha (PURA)

About Transcriptional activator protein Pur-alpha

Transcriptional activator protein Pur-alpha (PURA) is a protein from Homo sapiens identified by UniProt accession Q00577, 322 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.

Target properties

Protein name	Transcriptional activator protein Pur-alpha
UniProt accession	Q00577
Gene	PURA
Organism	Homo sapiens
Length	322 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (125)

Diseases linked to this target (Open Targets).

PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation · score 0.79
Intellectual disability · score 0.70
genetic disorder · score 0.54
neurodegenerative disease · score 0.53
Global developmental delay · score 0.52
Neonatal hypotonia · score 0.52
Delayed speech and language development · score 0.52
Seizure · score 0.51
complex neurodevelopmental disorder · score 0.37
mathematical ability · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00577-F1	alphafold	PREDICTED	78.16	—

Amino-acid sequence (322 residues)

MADRDSGSEQ GGAALGSGGS LGHPGSGSGS GGGGGGGGGG GGSGGGGGGA PGGLQHETQE LASKRVDIQN KRFYLDVKQN AKGRFLKIAE VGAGGNKSRL TLSMSVAVEF RDYLGDFIEH YAQLGPSQPP DLAQAQDEPR RALKSEFLVR ENRKYYMDLK ENQRGRFLRI RQTVNRGPGL GSTQGQTIAL PAQGLIEFRD ALAKLIDDYG VEEEPAELPE GTSLTVDNKR FFFDVGSNKY GVFMRVSEVK PTYRNSITVP YKVWAKFGHT FCKYSEEMKK IQEKQREKRA ACEQLHQQQQ QQQEETAAAT LLLQGEEEGE ED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards