Norrin (NDP)

About Norrin

Norrin (NDP) is a protein from Homo sapiens identified by UniProt accession Q00604, 133 residues long. MolForge cross-references it against 0 known binders and 354 disease associations.

Target properties

Protein name	Norrin
UniProt accession	Q00604
Gene	NDP
Organism	Homo sapiens
Length	133 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (354)

Diseases linked to this target (Open Targets).

Norrie disease · score 0.86
exudative vitreoretinopathy 2, X-linked · score 0.77
Familial exudative vitreoretinopathy · score 0.76
persistent hyperplastic primary vitreous · score 0.44
Myopia · score 0.28
retinal detachment · score 0.27
Nystagmus · score 0.27
Short lingual frenulum · score 0.27
Hearing impairment · score 0.27
pathological myopia · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00604-F1	alphafold	PREDICTED	83.58	—

Amino-acid sequence (133 residues)

MRKHVLAASF SMLSLLVIMG DTDSKTDSSF IMDSDPRRCM RHHYVDSISH PLYKCSSKMV LLARCEGHCS QASRSEPLVS FSTVLKQPFR SSCHCCRPQT SKLKALRLRC SGGMRLTATY RYILSCHCEE CNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards