About Heat shock factor protein 1
Heat shock factor protein 1 (HSF1) is a protein
from Homo sapiens identified by UniProt accession
Q00613, 529 residues long.
MolForge cross-references it against 0 known binders and
200 disease associations.
Target properties
| Protein name | Heat shock factor protein 1 |
|---|
| UniProt accession | Q00613 |
|---|
| Gene | HSF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 529 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (200)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- type 2 diabetes mellitus · score 0.15
- glucose measurement · score 0.13
- heel bone mineral density · score 0.11
- hepatocellular carcinoma · score 0.10
- Fasciitis · score 0.10
- Huntington disease · score 0.10
- urinary bladder cancer · score 0.09
- acute myeloid leukemia · score 0.09
- HbA1c measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00613-F1 | alphafold | PREDICTED | 61.30 | — |
Amino-acid sequence (529 residues)
MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS
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