Peptidyl-prolyl cis-trans isomerase FKBP3 (FKBP3)

About Peptidyl-prolyl cis-trans isomerase FKBP3

Peptidyl-prolyl cis-trans isomerase FKBP3 (FKBP3) is a protein from Homo sapiens identified by UniProt accession Q00688, 224 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase FKBP3
UniProt accession	Q00688
Gene	FKBP3
Organism	Homo sapiens
Length	224 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (33)

Diseases linked to this target (Open Targets).

nicotine dependence symptom count · score 0.08
non-small cell lung carcinoma · score 0.07
diffuse large B-cell lymphoma · score 0.07
sphingomyelin measurement · score 0.06
lung adenocarcinoma · score 0.06
age at menopause · score 0.06
self reported educational attainment · score 0.03
metabolite measurement · score 0.03
neoplasm · score 0.03
pyelonephritis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00688-F1	alphafold	PREDICTED	77.06	—

Amino-acid sequence (224 residues)

MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards