Myosin-binding protein C, slow-type (MYBPC1)

About Myosin-binding protein C, slow-type

Myosin-binding protein C, slow-type (MYBPC1) is a protein from Homo sapiens identified by UniProt accession Q00872, 1141 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Myosin-binding protein C, slow-type
UniProt accession	Q00872
Gene	MYBPC1
Organism	Homo sapiens
Length	1141 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

Lethal congenital contracture syndrome type 3 · score 0.72
digitotalar dysmorphism · score 0.68
congenital myopathy · score 0.62
Disorder of bilirubin metabolism and excretion · score 0.60
distal arthrogryposis · score 0.45
genetic disorder · score 0.41
adolescent idiopathic scoliosis · score 0.31
MAP kinase-activated protein kinase 3 measurement · score 0.30
Abnormality of the musculature · score 0.27
breast adenocarcinoma · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00872-F1	alphafold	PREDICTED	81.73	—

Amino-acid sequence (1141 residues)

MPEPTKKEEN EVPAPAPPPE EPSKEKEAGT TPAKDWTLVE TPPGEEQAKQ NANSQLSILF IEKPQGGTVK VGEDITFIAK VKAEDLLRKP TIKWFKGKWM DLASKAGKHL QLKETFERHS RVYTFEMQII KAKDNFAGNY RCEVTYKDKF DSCSFDLEVH ESTGTTPNID IRSAFKRSGE GQEDAGELDF SGLLKRREVK QQEEEPQVDV WELLKNAKPS EYEKIAFQYG ITDLRGMLKR LKRMRREEKK SAAFAKILDP AYQVDKGGRV RFVVELADPK LEVKWYKNGQ EIRPSTKYIF EHKGCQRILF INNCQMTDDS EYYVTAGDEK CSTELFVREP PIMVTKQLED TTAYCGERVE LECEVSEDDA NVKWFKNGEE IIPGPKSRYR IRVEGKKHIL IIEGATKADA AEYSVMTTGG QSSAKLSVDL KPLKILTPLT DQTVNLGKEI CLKCEISENI PGKWTKNGLP VQESDRLKVV HKGRIHKLVI ANALTEDEGD YVFAPDAYNV TLPAKVHVID PPKIILDGLD ADNTVTVIAG NKLRLEIPIS GEPPPKAMWS RGDKAIMEGS GRIRTESYPD SSTLVIDIAE RDDSGVYHIN LKNEAGEAHA SIKVKVVDFP DPPVAPTVTE VGDDWCIMNW EPPAYDGGSP ILGYFIERKK KQSSRWMRLN FDLCKETTFE PKKMIEGVAY EVRIFAVNAI GISKPSMPSR PFVPLAVTSP PTLLTVDSVT DTTVTMRWRP PDHIGAAGLD GYVLEYCFEG STSAKQSDEN GEAAYDLPAE DWIVANKDLI DKTKFTITGL PTDAKIFVRV KAVNAAGASE PKYYSQPILV KEIIEPPKIR IPRHLKQTYI RRVGEAVNLV IPFQGKPRPE LTWKKDGAEI DKNQINIRNS ETDTIIFIRK AERSHSGKYD LQVKVDKFVE TASIDIQIID RPGPPQIVKI EDVWGENVAL TWTPPKDDGN AAITGYTIQK ADKKSMEWFT VIEHYHRTSA TITELVIGNE YYFRVFSENM CGLSEDATMT KESAVIARDG KIYKNPVYED FDFSEAPMFT QPLVNTYAIA GYNATLNCSV RGNPKPKITW MKNKVAIVDD PRYRMFSNQG VCTLEIRKPS PYDGGTYCCK AVNDLGTVEI ECKLEVKVIA Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards