About Pregnancy-specific beta-1-glycoprotein 4
Pregnancy-specific beta-1-glycoprotein 4 (PSG4) is a protein
from Homo sapiens identified by UniProt accession
Q00888, 419 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Pregnancy-specific beta-1-glycoprotein 4 |
|---|
| UniProt accession | Q00888 |
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| Gene | PSG4 |
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| Organism | Homo sapiens |
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| Length | 419 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (60)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.32
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- thyroid gland adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.11
- low grade glioma · score 0.10
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- LIPE-related familial partial lipodystrophy · score 0.04
- obesity due to leptin receptor gene deficiency · score 0.04
- AXIN2-related attenuated familial adenomatous polyposis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00888-F1 | alphafold | PREDICTED | 86.70 | — |
Amino-acid sequence (419 residues)
MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS KPYITINNLN PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP
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