Pregnancy-specific beta-1-glycoprotein 6 (PSG6)

About Pregnancy-specific beta-1-glycoprotein 6

Pregnancy-specific beta-1-glycoprotein 6 (PSG6) is a protein from Homo sapiens identified by UniProt accession Q00889, 435 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Pregnancy-specific beta-1-glycoprotein 6
UniProt accession	Q00889
Gene	PSG6
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.42
glioblastoma multiforme · score 0.18
visual perception measurement · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
head and neck squamous cell carcinoma · score 0.11
low grade glioma · score 0.10
obesity due to melanocortin 4 receptor deficiency · score 0.06
LIPE-related familial partial lipodystrophy · score 0.04
obesity due to leptin receptor gene deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00889-F1	alphafold	PREDICTED	85.40	—

Amino-acid sequence (435 residues)

MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD VLLLVHNLPQ NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV YSNASLLIQN VTQEDAGSYT LHIIKRGDGT GGVTGYFTVT LYSETPKPSI SSSNLNPREV MEAVRLICDP ETPDASYLWL LNGQNLPMTH RLQLSKTNRT LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM PYITINNLNP REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD LSCFADSNPP AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT GKEISKSMIV KVSETASPQV TYAGPNTWFQ EILLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards