About Epithelial cell-transforming sequence 2 oncogene-like
Epithelial cell-transforming sequence 2 oncogene-like (ECT2L) is a protein
from Homo sapiens identified by UniProt accession
Q008S8, 904 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Epithelial cell-transforming sequence 2 oncogene-like |
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| UniProt accession | Q008S8 |
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| Gene | ECT2L |
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| Organism | Homo sapiens |
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| Length | 904 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (116)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.21
- chronic lymphocytic leukemia · score 0.18
- oral squamous cell carcinoma · score 0.18
- breast carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- hepatocellular carcinoma · score 0.18
- acute myeloid leukemia · score 0.18
- T-cell acute lymphoblastic leukemia · score 0.18
- gastric carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q008S8-F1 | alphafold | PREDICTED | 74.49 | — |
Amino-acid sequence (904 residues)
MESFHTRFSA WTPFSNKSLN RQLFQERVAL ISHWFDLWTN KQRQEFLFAI FLRCTKSQLR FVQDWFSERM QVAKVDFSTV LPRFISLYIF SFLSPKDLCA AAQVSWPWKF LTEQDCLWMP KCVKFGWFLP YTPTDNEYGA WKRHYIACVS HLDWLTPREA AATYGTLNEP KTEDEELLER QREKCLRKRI WEKIALRKKE LFKVRPPWVS GTCCSSVLKP RCQPRLSQTV RERVGLHEAL EKQLVLTSLE TLPKRSNISG SHSYPLLSKK NWHGVHKNDD RSSYALRPHF MLISSRIPAY EMVMESVKAG VVSVVYEHSV TLESLLYLIE KALDGQKAQS IGIFSDGDSR EINLLQGYKI GVKNLLRPEV RDFWEKLGSY VATEEEGGHV DFFVPLGASE AGIEVLSQLS QLTGTFFTAP TGIATGSYQH ILSDWLGSQW GKAPSSIYFC ESKLQTWSSF TDFLEETLKT VRKQLYPFFK ELQKSISGRM IGQFMFDTMG MTNILNNQDT AQALADGLME LSKEDSERNV VEDNSWDTKS RLSKNDLNFE ALINLERILQ KDSAEKRARV VRELLQSERK YVQILEIVRD VYVAPLKAAL SSNRAILSAA NIQIIFCDIL QILSLNRQFL DNLRDRLQEW GPAHCVGEIV TKFGSQLNTY TNFFNNYPVI LKTIEKCREM IPAFRTFLKR HDKTIVTKML SLPELLLYPS RRFEEYLNLL YAVRLHTPAE HVDRGDLTTA IDQIKKYKGY IDQMKQNITM KDHLSDIQRI IWGCPTLSEV NRYLIRVQDV AQLHCCDEEI SFSLRLYEHI HDLSLFLFND ALLVSSRGTS HTPFERTSKT TYQFIASVAL HRLLIENIPD SKYVKNAFIL QGPKYKWICA TEIEDDKFLW LSVLRNAIKS SMEK
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