About Beta-1,4 N-acetylgalactosaminyltransferase 1
Beta-1,4 N-acetylgalactosaminyltransferase 1 (B4GALNT1) is a protein
from Homo sapiens identified by UniProt accession
Q00973, 533 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Beta-1,4 N-acetylgalactosaminyltransferase 1 |
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| UniProt accession | Q00973 |
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| Gene | B4GALNT1 |
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| Organism | Homo sapiens |
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| Length | 533 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (155)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 26 · score 0.78
- hereditary spastic paraplegia 26 · score 0.77
- Spastic paraplegia · score 0.55
- genetic disorder · score 0.48
- complex hereditary spastic paraplegia · score 0.37
- neurodegenerative disease · score 0.33
- hepatocellular carcinoma · score 0.09
- azoospermia · score 0.09
- neoplasm · score 0.08
- cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00973-F1 | alphafold | PREDICTED | 88.67 | — |
Amino-acid sequence (533 residues)
MWLGRRALCA LVLLLACASL GLLYASTRDA PGLRLPLAPW APPQSPRRPE LPDLAPEPRY AHIPVRIKEQ VVGLLAWNNC SCESSGGGLP LPFQKQVRAI DLTKAFDPAE LRAASATREQ EFQAFLSRSQ SPADQLLIAP ANSPLQYPLQ GVEVQPLRSI LVPGLSLQAA SGQEVYQVNL TASLGTWDVA GEVTGVTLTG EGQADLTLVS PGLDQLNRQL QLVTYSSRSY QTNTADTVRF STEGHEAAFT IRIRHPPNPR LYPPGSLPQG AQYNISALVT IATKTFLRYD RLRALITSIR RFYPTVTVVI ADDSDKPERV SGPYVEHYLM PFGKGWFAGR NLAVSQVTTK YVLWVDDDFV FTARTRLERL VDVLERTPLD LVGGAVREIS GFATTYRQLL SVEPGAPGLG NCLRQRRGFH HELVGFPGCV VTDGVVNFFL ARTDKVREVG FDPRLSRVAH LEFFLDGLGS LRVGSCSDVV VDHASKLKLP WTSRDAGAET YARYRYPGSL DESQMAKHRL LFFKHRLQCM TSQ
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