About Interferon regulatory factor 9
Interferon regulatory factor 9 (IRF9) is a protein
from Homo sapiens identified by UniProt accession
Q00978, 393 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | Interferon regulatory factor 9 |
|---|
| UniProt accession | Q00978 |
|---|
| Gene | IRF9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 393 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (158)
Diseases linked to this target (Open Targets).
- immunodeficiency disease · score 0.47
- pancreatic adenocarcinoma · score 0.18
- apolipoprotein A 1 measurement · score 0.14
- neoplasm · score 0.11
- nonpapillary renal cell carcinoma · score 0.08
- pulmonary arterial hypertension · score 0.07
- varicella, severe recurrent · score 0.07
- candidiasis, familial, 4 · score 0.07
- cancer · score 0.06
- acute promyelocytic leukemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00978-F1 | alphafold | PREDICTED | 74.57 | — |
Amino-acid sequence (393 residues)
MASGRARCTR KLRNWVVEQV ESGQFPGVCW DDTAKTMFRI PWKHAGKQDF REDQDAAFFK AWAIFKGKYK EGDTGGPAVW KTRLRCALNK SSEFKEVPER GRMDVAEPYK VYQLLPPGIV SGQPGTQKVP SKRQHSSVSS ERKEEEDAMQ NCTLSPSVLQ DSLNNEEEGA SGGAVHSDIG SSSSSSSPEP QEVTDTTEAP FQGDQRSLEF LLPPEPDYSL LLTFIYNGRV VGEAQVQSLD CRLVAEPSGS ESSMEQVLFP KPGPLEPTQR LLSQLERGIL VASNPRGLFV QRLCPIPISW NAPQAPPGPG PHLLPSNECV ELFRTAYFCR DLVRYFQGLG PPPKFQVTLN FWEESHGSSH TPQNLITVKM EQAFARYLLE QTPEQQAAIL SLV
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