About E3 ubiquitin-protein ligase Mdm2
E3 ubiquitin-protein ligase Mdm2 (MDM2) is a protein
from Homo sapiens identified by UniProt accession
Q00987, 491 residues long.
MolForge cross-references it against 0 known binders and
986 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase Mdm2 |
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| UniProt accession | Q00987 |
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| Gene | MDM2 |
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| Organism | Homo sapiens |
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| Length | 491 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (986)
Diseases linked to this target (Open Targets).
- Lessel-Kubisch syndrome · score 0.45
- mean corpuscular volume · score 0.41
- erythrocyte count · score 0.41
- cancer · score 0.40
- acute myeloid leukemia · score 0.39
- Li-Fraumeni syndrome · score 0.39
- skin basal cell carcinoma · score 0.37
- prostate carcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- hemangioblastoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00987-F1 | alphafold | PREDICTED | 62.58 | — |
Amino-acid sequence (491 residues)
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ PIQMIVLTYF P
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