Perilipin-5 (PLIN5)

About Perilipin-5

Perilipin-5 (PLIN5) is a protein from Homo sapiens identified by UniProt accession Q00G26, 463 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.

Target properties

Protein name	Perilipin-5
UniProt accession	Q00G26
Gene	PLIN5
Organism	Homo sapiens
Length	463 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (99)

Diseases linked to this target (Open Targets).

non-alcoholic fatty liver disease · score 0.09
non-alcoholic steatohepatitis · score 0.08
hepatocellular carcinoma · score 0.08
Wilson disease · score 0.05
gonorrhea · score 0.05
myocardial infarction · score 0.05
cardiac hypertrophy · score 0.04
LIPE-related familial partial lipodystrophy · score 0.04
Insulin resistance · score 0.04
type 2 diabetes mellitus · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00G26-F1	alphafold	PREDICTED	66.52	—

Amino-acid sequence (463 residues)

MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH PLLGSACRLA ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL EEKLPFLQQP SETVVTSAKD VVASSVTGVV DLARRGRRWS VELKRSVSHA VDVVLEKSEE LVDHFLPMTE EELAALAAEA EGPEVGSVED QRRQQGYFVR LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL IDHMQCGVTP TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR VAHAHACVDE LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI GGPDPRWAHL DWPAQQRAWE AEHRDGSGNG DGDRMGVAGD ICEQEPETPS CPVKHTLMPE LDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards