Splicing factor U2AF 35 kDa subunit (U2AF1)

About Splicing factor U2AF 35 kDa subunit

Splicing factor U2AF 35 kDa subunit (U2AF1) is a protein from Homo sapiens identified by UniProt accession Q01081, 240 residues long. MolForge cross-references it against 0 known binders and 279 disease associations.

Target properties

Protein name	Splicing factor U2AF 35 kDa subunit
UniProt accession	Q01081
Gene	U2AF1
Organism	Homo sapiens
Length	240 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (279)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.60
lung adenocarcinoma · score 0.55
neurodegenerative disease · score 0.50
myelodysplastic syndrome · score 0.48
non-small cell lung carcinoma · score 0.44
pancreatic adenocarcinoma · score 0.43
Uterine Carcinosarcoma · score 0.41
cervical adenocarcinoma · score 0.39
head and neck squamous cell carcinoma · score 0.39
bladder transitional cell carcinoma · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01081-F1	alphafold	PREDICTED	79.23	—

Amino-acid sequence (240 residues)

MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRLHNKP TFSQTIALLN IYRNPQNSSQ SADGLRCAVS DVEMQEHYDE FFEEVFTEME EKYGEVEEMN VCDNLGDHLV GNVYVKFRRE EDAEKAVIDL NNRWFNGQPI HAELSPVTDF REACCRQYEM GECTRGGFCN FMHLKPISRE LRRELYGRRR KKHRSRSRSR ERRSRSRDRG RGGGGGGGGG GGGRERDRRR SRDRERSGRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards