Transcription factor E2F1 (E2F1)

About Transcription factor E2F1

Transcription factor E2F1 (E2F1) is a protein from Homo sapiens identified by UniProt accession Q01094, 437 residues long. MolForge cross-references it against 0 known binders and 267 disease associations.

Target properties

Protein name	Transcription factor E2F1
UniProt accession	Q01094
Gene	E2F1
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (267)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
multiple sclerosis · score 0.30
Parkinson disease · score 0.30
Alzheimer disease · score 0.30
lysosomal storage disease · score 0.30
lung adenocarcinoma · score 0.29
endometrial cancer · score 0.29
head and neck squamous cell carcinoma · score 0.29
breast adenocarcinoma · score 0.29
small cell lung carcinoma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01094-F1	alphafold	PREDICTED	62.03	—

Amino-acid sequence (437 residues)

MALAGAPAGG PCAPALEALL GAGALRLLDS SQIVIISAAQ DASAPPAPTG PAAPAAGPCD PDLLLFATPQ APRPTPSAPR PALGRPPVKR RLDLETDHQY LAESSGPARG RGRHPGKGVK SPGEKSRYET SLNLTTKRFL ELLSHSADGV VDLNWAAEVL KVQKRRIYDI TNVLEGIQLI AKKSKNHIQW LGSHTTVGVG GRLEGLTQDL RQLQESEQQL DHLMNICTTQ LRLLSEDTDS QRLAYVTCQD LRSIADPAEQ MVMVIKAPPE TQLQAVDSSE NFQISLKSKQ GPIDVFLCPE ETVGGISPGK TPSQEVTSEE ENRATDSATI VSPPPSSPPS SLTTDPSQSL LSLEQEPLLS RMGSLRAPVD EDRLSPLVAA DSLLEHVRED FSGLLPEEFI SLSPPHEALD YHFGLEEGEG IRDLFDCDFG DLTPLDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards