Insulinoma-associated protein 1 (INSM1)

About Insulinoma-associated protein 1

Insulinoma-associated protein 1 (INSM1) is a protein from Homo sapiens identified by UniProt accession Q01101, 510 residues long. MolForge cross-references it against 0 known binders and 273 disease associations.

Target properties

Protein name	Insulinoma-associated protein 1
UniProt accession	Q01101
Gene	INSM1
Organism	Homo sapiens
Length	510 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (273)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
age at menarche · score 0.31
appendicular lean mass · score 0.28
sitting height measurement · score 0.21
insulin like growth factor measurement · score 0.21
head and neck squamous cell carcinoma · score 0.18
body height · score 0.12
neoplasm · score 0.10
small cell lung carcinoma · score 0.09
lymphocyte count · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01101-F1	alphafold	PREDICTED	58.38	—

Amino-acid sequence (510 residues)

MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS SPGLTRHINK CHPSENRQVI LLQVPVRPAC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards