Protein SET (SET)

About Protein SET

Protein SET (SET) is a protein from Homo sapiens identified by UniProt accession Q01105, 290 residues long. MolForge cross-references it against 0 known binders and 227 disease associations.

Target properties

Protein name	Protein SET
UniProt accession	Q01105
Gene	SET
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (227)

Diseases linked to this target (Open Targets).

intellectual disability, autosomal dominant 58 · score 0.74
Intellectual disability · score 0.50
neurodegenerative disease · score 0.49
genetic disorder · score 0.46
acute lymphoblastic leukemia · score 0.38
T-cell acute lymphoblastic leukemia · score 0.37
autosomal dominant non-syndromic intellectual disability · score 0.37
Global developmental delay · score 0.34
hepatocellular carcinoma · score 0.31
acute myeloid leukemia · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01105-F1	alphafold	PREDICTED	77.60	—

Amino-acid sequence (290 residues)

MAPKRQSPLP PQKKKPRPPP ALGPEETSAS AGLPKKGEKE QQEAIEHIDE VQNEIDRLNE QASEEILKVE QKYNKLRQPF FQKRSELIAK IPNFWVTTFV NHPQVSALLG EEDEEALHYL TRVEVTEFED IKSGYRIDFY FDENPYFENK VLSKEFHLNE SGDPSSKSTE IKWKSGKDLT KRSSQTQNKA SRKRQHEEPE SFFTWFTDHS DAGADELGEV IKDDIWPNPL QYYLVPDMDD EEGEGEEDDD DDEEEEGLED IDEEGDEDEG EEDEDDDEGE EGEEDEGEDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards