About Runt-related transcription factor 1
Runt-related transcription factor 1 (RUNX1) is a protein
from Homo sapiens identified by UniProt accession
Q01196, 453 residues long.
MolForge cross-references it against 0 known binders and
1,142 disease associations.
Target properties
| Protein name | Runt-related transcription factor 1 |
|---|
| UniProt accession | Q01196 |
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| Gene | RUNX1 |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1142)
Diseases linked to this target (Open Targets).
- hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 · score 0.80
- acute myeloid leukemia · score 0.75
- hereditary thrombocytopenia and hematologic cancer predisposition syndrome · score 0.68
- Thrombocytopenia · score 0.66
- Abnormal bleeding · score 0.51
- neurodegenerative disease · score 0.46
- acute lymphoblastic leukemia · score 0.45
- platelet count · score 0.44
- platelet crit · score 0.42
- breast adenocarcinoma · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01196-F1 | alphafold | PREDICTED | 61.00 | — |
Amino-acid sequence (453 residues)
MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDAGAAL AGKLRSGDRS MVEVLADHPG ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRRHR QKLDDQTKPG SLSFSERLSE LEQLRRTAMR VSPHHPAPTP NPRASLNHST AFNPQPQSQM QDTRQIQPSP PWSYDQSYQY LGSIASPSVH PATPISPGRA SGMTTLSAEL SSRLSTAPDL TAFSDPRQFP ALPSISDPRM HYPGAFTYSP TPVTSGIGIG MSAMGSATRY HTYLPPPYPG SSQAQGGPFQ ASSPSYHLYY GASAGSYQFS MVGGERSPPR ILPPCTNAST GSALLNPSLP NQSDVVEAEG SHSNSPTNMA PSARLEEAVW RPY
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