About Interleukin-5 receptor subunit alpha
Interleukin-5 receptor subunit alpha (IL5RA) is a protein
from Homo sapiens identified by UniProt accession
Q01344, 420 residues long.
MolForge cross-references it against 0 known binders and
306 disease associations.
Target properties
| Protein name | Interleukin-5 receptor subunit alpha |
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| UniProt accession | Q01344 |
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| Gene | IL5RA |
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| Organism | Homo sapiens |
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| Length | 420 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (306)
Diseases linked to this target (Open Targets).
- asthma · score 0.59
- eosinophil count · score 0.53
- eosinophil percentage of leukocytes · score 0.52
- basophil count · score 0.48
- basophil percentage of leukocytes · score 0.47
- interleukin 5 receptor subunit alpha measurement · score 0.46
- basophil percentage of granulocytes · score 0.44
- blood protein measurement · score 0.39
- chronic idiopathic urticaria · score 0.38
- Nasal Cavity Polyp · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01344-F1 | alphafold | PREDICTED | 83.81 | — |
Amino-acid sequence (420 residues)
MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT ILQNDHSLLA SSWASAELHA PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE ECQEYSKDTL GRNIACWFPR TFILSKGRDW LAVLVNGSSK HSAIRPFDQL FALHAIDQIN PPLNVTAEIE GTRLSIQWEK PVSAFPIHCF DYEVKIHNTR NGYLQIEKLM TNAFISIIDD LSKYDVQVRA AVSSMCREAG LWSEWSQPIY VGNDEHKPLR EWFVIVIMAT ICFILLILSL ICKICHLWIK LFPPIPAPKS NIKDLFVTTN YEKAGSSETE IEVICYIEKP GVETLEDSVF
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