N-acetylgalactosamine kinase (GALK2)

About N-acetylgalactosamine kinase

N-acetylgalactosamine kinase (GALK2) is a protein from Homo sapiens identified by UniProt accession Q01415, 458 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	N-acetylgalactosamine kinase
UniProt accession	Q01415
Gene	GALK2
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
FEV/FVC ratio · score 0.26
mean platelet volume · score 0.23
cortical thickness · score 0.19
psoriatic arthritis · score 0.15
multiple sclerosis · score 0.12
Alzheimer disease · score 0.12
lysosomal storage disease · score 0.12
Parkinson disease · score 0.12
thyroid stimulating hormone measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01415-F1	alphafold	PREDICTED	94.90	—

Amino-acid sequence (458 residues)

MATESPATRR VQVAEHPRLL KLKEMFNSKF GSIPKFYVRA PGRVNIIGEH IDYCGYSVLP MAVEQDVLIA VEPVKTYALQ LANTNPLYPD FSTSANNIQI DKTKPLWHNY FLCGLKGIQE HFGLSNLTGM NCLVDGNIPP SSGLSSSSAL VCCAGLVTLT VLGRNLSKVE LAEICAKSER YIGTEGGGMD QSISFLAEEG TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF NIRVMECRLA AKLLAKYKSL QWDKVLRLEE VQAKLGISLE EMLLVTEDAL HPEPYNPEEI CRCLGISLEE LRTQILSPNT QDVLIFKLYQ RAKHVYSEAA RVLQFKKICE EAPENMVQLL GELMNQSHMS CRDMYECSCP ELDQLVDICR KFGAQGSRLT GAGWGGCTVS MVPADKLPSF LANVHKAYYQ RSDGSLAPEK QSLFATKPGG GALVLLEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards