About AMP deaminase 2
AMP deaminase 2 (AMPD2) is a protein
from Homo sapiens identified by UniProt accession
Q01433, 825 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | AMP deaminase 2 |
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| UniProt accession | Q01433 |
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| Gene | AMPD2 |
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| Organism | Homo sapiens |
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| Length | 825 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 9 · score 0.79
- pontocerebellar hypoplasia · score 0.65
- hereditary spastic paraplegia 63 · score 0.63
- hereditary spastic paraplegia · score 0.53
- Autosomal recessive spastic paraplegia type 63 · score 0.46
- Non-syndromic pontocerebellar hypoplasia · score 0.41
- genetic disorder · score 0.38
- Abnormality of the nervous system · score 0.34
- spastic ataxia · score 0.34
- body mass index · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01433-F1 | alphafold | PREDICTED | 80.66 | — |
Amino-acid sequence (825 residues)
MASYPSGSGK PKAKYPFKKR ASLQASTAAP EARGGLGAPP LQSARSLPGP APCLKHFPLD LRTSMDGKCK EIAEELFTRS LAESELRSAP YEFPEESPIE QLEERRQRLE RQISQDVKLE PDILLRAKQD FLKTDSDSDL QLYKEQGEGQ GDRSLRERDV LEREFQRVTI SGEEKCGVPF TDLLDAAKSV VRALFIREKY MALSLQSFCP TTRRYLQQLA EKPLETRTYE QGPDTPVSAD APVHPPALEQ HPYEHCEPST MPGDLGLGLR MVRGVVHVYT RREPDEHCSE VELPYPDLQE FVADVNVLMA LIINGPIKSF CYRRLQYLSS KFQMHVLLNE MKELAAQKKV PHRDFYNIRK VDTHIHASSC MNQKHLLRFI KRAMKRHLEE IVHVEQGREQ TLREVFESMN LTAYDLSVDT LDVHADRNTF HRFDKFNAKY NPIGESVLRE IFIKTDNRVS GKYFAHIIKE VMSDLEESKY QNAELRLSIY GRSRDEWDKL ARWAVMHRVH SPNVRWLVQV PRLFDVYRTK GQLANFQEML ENIFLPLFEA TVHPASHPEL HLFLEHVDGF DSVDDESKPE NHVFNLESPL PEAWVEEDNP PYAYYLYYTF ANMAMLNHLR RQRGFHTFVL RPHCGEAGPI HHLVSAFMLA ENISHGLLLR KAPVLQYLYY LAQIGIAMSP LSNNSLFLSY HRNPLPEYLS RGLMVSLSTD DPLQFHFTKE PLMEEYSIAT QVWKLSSCDM CELARNSVLM SGFSHKVKSH WLGPNYTKEG PEGNDIRRTN VPDIRVGYRY ETLCQELALI TQAVQSEMLE TIPEEAGITM SPGPQ
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