About Myosin regulatory light chain 2, atrial isoform
Myosin regulatory light chain 2, atrial isoform (MYL7) is a protein
from Homo sapiens identified by UniProt accession
Q01449, 175 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Myosin regulatory light chain 2, atrial isoform |
|---|
| UniProt accession | Q01449 |
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| Gene | MYL7 |
|---|
| Organism | Homo sapiens |
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| Length | 175 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.55
- cardiovascular disease · score 0.37
- heart failure · score 0.35
- Reduced left ventricular ejection fraction · score 0.28
- glucose measurement · score 0.26
- HbA1c measurement · score 0.23
- type 2 diabetes mellitus · score 0.17
- fasting blood glucose measurement · score 0.17
- triglyceride measurement · score 0.13
- heart rate · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01449-F1 | alphafold | PREDICTED | 82.90 | — |
Amino-acid sequence (175 residues)
MASRKAGTRG KVAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG IICKADLRET YSQLGKVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG TDPEEAILSA FRMFDPSGKG VVNKDEFKQL LLTQADKFSP AEVEQMFALT PMDLAGNIDY KSLCYIITHG DEKEE
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