About Peripheral myelin protein 22
Peripheral myelin protein 22 (PMP22) is a protein
from Homo sapiens identified by UniProt accession
Q01453, 160 residues long.
MolForge cross-references it against 0 known binders and
684 disease associations.
Target properties
| Protein name | Peripheral myelin protein 22 |
|---|
| UniProt accession | Q01453 |
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| Gene | PMP22 |
|---|
| Organism | Homo sapiens |
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| Length | 160 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (684)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 1A · score 0.82
- Dejerine-Sottas syndrome · score 0.81
- Charcot-Marie-Tooth disease type 1E · score 0.78
- hereditary neuropathy with liability to pressure palsies · score 0.78
- Charcot-Marie-Tooth disease type 3 · score 0.78
- chronic inflammatory demyelinating polyneuropathy · score 0.58
- Charcot-Marie-Tooth disease type 1 · score 0.56
- Charcot-Marie-Tooth disease · score 0.54
- Roussy-Lévy syndrome · score 0.54
- genetic disorder · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01453-F1 | alphafold | PREDICTED | 89.98 | — |
Amino-acid sequence (160 residues)
MLLLLLSIIV LHVAVLVLLF VSTIVSQWIV GNGHATDLWQ NCSTSSSGNV HHCFSSSPNE WLQSVQATMI LSIIFSILSL FLFFCQLFTL TKGGRFYITG IFQILAGLCV MSAAAIYTVR HPEWHLNSDY SYGFAYILAW VAFPLALLSG VIYVILRKRE
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