Di-N-acetylchitobiase (CTBS)

About Di-N-acetylchitobiase

Di-N-acetylchitobiase (CTBS) is a protein from Homo sapiens identified by UniProt accession Q01459, 385 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Di-N-acetylchitobiase
UniProt accession	Q01459
Gene	CTBS
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

optic cup area measurement · score 0.15
MODY · score 0.11
type 2 diabetes mellitus · score 0.08
type 1 diabetes mellitus · score 0.07
diabetes mellitus, transient neonatal, 2 · score 0.07
hyperinsulinism due to glucokinase deficiency · score 0.05
Dent disease · score 0.04
pentosuria · score 0.03
primary hyperoxaluria type 3 · score 0.03
Acute hepatic failure · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01459-F1	alphafold	PREDICTED	91.61	—

Amino-acid sequence (385 residues)

MSRPQLRRWR LVSSPPSGVP GLALLALLAL LALRLAAGTD CPCPEPELCR PIRHHPDFEV FVFDVGQKTW KSYDWSQITT VATFGKYDSE LMCYAHSKGA RVVLKGDVSL KDIIDPAFRA SWIAQKLNLA KTQYMDGINI DIEQEVNCLS PEYDALTALV KETTDSFHRE IEGSQVTFDV AWSPKNIDRR CYNYTGIADA CDFLFVMSYD EQSQIWSECI AAANAPYNQT LTGYNDYIKM SINPKKLVMG VPWYGYDYTC LNLSEDHVCT IAKVPFRGAP CSDAAGRQVP YKTIMKQINS SISGNLWDKD QRAPYYNYKD PAGHFHQVWY DNPQSISLKA TYIQNYRLRG IGMWNANCLD YSGDAVAKQQ TEEMWEVLKP KLLQR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards