Defensin alpha 5 (DEFA5)

About Defensin alpha 5

Defensin alpha 5 (DEFA5) is a protein from Homo sapiens identified by UniProt accession Q01523, 94 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Defensin alpha 5
UniProt accession	Q01523
Gene	DEFA5
Organism	Homo sapiens
Length	94 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

basophil count · score 0.42
monocyte count · score 0.38
basophil percentage of leukocytes · score 0.38
monocyte percentage of leukocytes · score 0.36
IGA glomerulonephritis · score 0.29
neutrophil count · score 0.28
granulocyte percentage of myeloid white cells · score 0.23
cutaneous melanoma · score 0.22
myeloid white cell count · score 0.22
sum of basophil and neutrophil counts · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01523-F1	alphafold	PREDICTED	70.64	—

Amino-acid sequence (94 residues)

MRTIAILAAI LLVALQAQAE SLQERADEAT TQKQSGEDNQ DLAISFAGNG LSALRTSGSQ ARATCYCRTG RCATRESLSG VCEISGRLYR LCCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards