Defensin-6 (DEFA6)

About Defensin-6

Defensin-6 (DEFA6) is a protein from Homo sapiens identified by UniProt accession Q01524, 100 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Defensin-6
UniProt accession	Q01524
Gene	DEFA6
Organism	Homo sapiens
Length	100 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.22
lung adenocarcinoma · score 0.22
basophil percentage of leukocytes · score 0.09
viral load · score 0.08
necrotizing enterocolitis · score 0.05
adenoma · score 0.05
lung carcinoma · score 0.04
monocyte count · score 0.04
IGA glomerulonephritis · score 0.04
Crohn's disease · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01524-F1	alphafold	PREDICTED	67.01	—

Amino-acid sequence (100 residues)

MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards