Testis-specific Y-encoded protein 1 (TSPY1)

About Testis-specific Y-encoded protein 1

Testis-specific Y-encoded protein 1 (TSPY1) is a protein from Homo sapiens identified by UniProt accession Q01534, 308 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Testis-specific Y-encoded protein 1
UniProt accession	Q01534
Gene	TSPY1
Organism	Homo sapiens
Length	308 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

partial chromosome Y deletion · score 0.37
neurodegenerative disease · score 0.22
gonadoblastoma · score 0.01
dysgerminoma · score 0.01
disorder of sexual differentiation · score 0.01
Ovarian Dysgerminoma · score 0.01
Infertility · score 0.01
Mayer-Rokitansky-Kuster-Hauser syndrome · score 0.00
childhood testicular germ cell tumor · score 0.00
male infertility · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01534-F1	alphafold	PREDICTED	73.54	—

Amino-acid sequence (308 residues)

MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESAPE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVG EEKHPVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET SGDSQLLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards