About Friend leukemia integration 1 transcription factor
Friend leukemia integration 1 transcription factor (FLI1) is a protein
from Homo sapiens identified by UniProt accession
Q01543, 452 residues long.
MolForge cross-references it against 0 known binders and
555 disease associations.
Target properties
| Protein name | Friend leukemia integration 1 transcription factor |
|---|
| UniProt accession | Q01543 |
|---|
| Gene | FLI1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 452 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (555)
Diseases linked to this target (Open Targets).
- Rare hemorrhagic disorder due to a constitutional platelet anomaly · score 0.67
- platelet count · score 0.51
- body height · score 0.50
- platelet crit · score 0.49
- eosinophil count · score 0.49
- monocyte count · score 0.48
- basophil count · score 0.48
- eosinophil percentage of leukocytes · score 0.43
- Ewing sarcoma · score 0.41
- monocyte percentage of leukocytes · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01543-F1 | alphafold | PREDICTED | 63.37 | — |
Amino-acid sequence (452 residues)
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS LMEIDTSFFQ NMDGKELCKM NKEDFLRATT LYNTEVLLSH LSYLRESSLL AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK SPPLGGAQTI SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF VPPHPSSMPV TSSSFFGAAS QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS YY
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