About Keratin, type II cytoskeletal 2 oral
Keratin, type II cytoskeletal 2 oral (KRT76) is a protein
from Homo sapiens identified by UniProt accession
Q01546, 638 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 2 oral |
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| UniProt accession | Q01546 |
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| Gene | KRT76 |
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| Organism | Homo sapiens |
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| Length | 638 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (209)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.19
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- low grade glioma · score 0.11
- hypotrichosis simplex · score 0.09
- uncombable hair syndrome · score 0.08
- Dowling-Degos disease · score 0.08
- Ichthyosis-hypotrichosis syndrome · score 0.07
- Alopecia-intellectual disability syndrome · score 0.07
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01546-F1 | alphafold | PREDICTED | 62.33 | — |
Amino-acid sequence (638 residues)
MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVARSGGAG GGACGFRSGA GSFGSRSLYN LGSNKSISIS VAAGSSRAGG FGGGRSSCGF AGGYGGGFGG SYGGGFGGGR GVGSGFGGAG GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK AQEREQIKTL NNKFASFIDK VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF LCKQLDSLLG ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMN KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL GSIIAEVRAQ YEEIAQRSKS EAEALYQTKL GELQTTAGRH GDDLRNTKSE IMELNRMIQR LRAEIENVKK QNANLQTAIA EAEQRGEMAL KDANAKLQDL QTALQKAKDD LARLLRDYQE LMNVKLALDV EIATYRKLLE GEECRMSGEC QSAVCISVVS NVTSTSGSSG SSRGVFGGVS GSGSGGYKGG SSSSSSSGYG VSGGSGSGYG GVSSGSTGGR GSSGSYQSSS SGSRLGGAGS ISVSHSGMGS SSGSIQTSGG SGYKSGGGGS TSIRFSQTTS SSQHSSTK
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