About Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) is a protein
from Homo sapiens identified by UniProt accession
Q01581, 520 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Hydroxymethylglutaryl-CoA synthase, cytoplasmic |
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| UniProt accession | Q01581 |
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| Gene | HMGCS1 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- rigid spine syndrome · score 0.51
- Red cell distribution width · score 0.35
- mathematical ability · score 0.27
- Alzheimer disease · score 0.23
- lysosomal storage disease · score 0.23
- Parkinson disease · score 0.23
- multiple sclerosis · score 0.23
- mean platelet volume · score 0.15
- acute myeloid leukemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01581-F1 | alphafold | PREDICTED | 91.33 | — |
Amino-acid sequence (520 residues)
MPGSLPLNAE ACWPKDVGIV ALEIYFPSQY VDQAELEKYD GVDAGKYTIG LGQAKMGFCT DREDINSLCM TVVQNLMERN NLSYDCIGRL EVGTETIIDK SKSVKTNLMQ LFEESGNTDI EGIDTTNACY GGTAAVFNAV NWIESSSWDG RYALVVAGDI AVYATGNARP TGGVGAVALL IGPNAPLIFE RGLRGTHMQH AYDFYKPDML SEYPIVDGKL SIQCYLSALD RCYSVYCKKI HAQWQKEGND KDFTLNDFGF MIFHSPYCKL VQKSLARMLL NDFLNDQNRD KNSIYSGLEA FGDVKLEDTY FDRDVEKAFM KASSELFSQK TKASLLVSNQ NGNMYTSSVY GSLASVLAQY SPQQLAGKRI GVFSYGSGLA ATLYSLKVTQ DATPGSALDK ITASLCDLKS RLDSRTGVAP DVFAENMKLR EDTHHLVNYI PQGSIDSLFE GTWYLVRVDE KHRRTYARRP TPNDDTLDEG VGLVHSNIAT EHIPSPAKKV PRLPATAAEP EAAVISNGEH
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