Interferon-induced transmembrane protein 3 (IFITM3)

About Interferon-induced transmembrane protein 3

Interferon-induced transmembrane protein 3 (IFITM3) is a protein from Homo sapiens identified by UniProt accession Q01628, 133 residues long. MolForge cross-references it against 0 known binders and 261 disease associations.

Target properties

Protein name	Interferon-induced transmembrane protein 3
UniProt accession	Q01628
Gene	IFITM3
Organism	Homo sapiens
Length	133 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (261)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.35
eosinophil percentage of leukocytes · score 0.31
creatinine measurement · score 0.26
neutrophil count · score 0.25
sex hormone-binding globulin measurement · score 0.25
monocyte count · score 0.23
neutrophil percentage of granulocytes · score 0.22
eosinophil percentage of granulocytes · score 0.21
platelet count · score 0.18
inflammatory bowel disease · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01628-F1	alphafold	PREDICTED	59.06	—

Amino-acid sequence (133 residues)

MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL LIVIPVLIFQ AYG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards