Interferon-induced transmembrane protein 2 (IFITM2)

About Interferon-induced transmembrane protein 2

Interferon-induced transmembrane protein 2 (IFITM2) is a protein from Homo sapiens identified by UniProt accession Q01629, 132 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Interferon-induced transmembrane protein 2
UniProt accession	Q01629
Gene	IFITM2
Organism	Homo sapiens
Length	132 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.35
leukocyte count · score 0.34
basophil count · score 0.33
erythrocyte count · score 0.33
eosinophil count · score 0.32
myeloid white cell count · score 0.32
monocyte percentage of leukocytes · score 0.31
neutrophil percentage of leukocytes · score 0.30
hemoglobin measurement · score 0.29
lymphocyte percentage of leukocytes · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01629-F1	alphafold	PREDICTED	61.54	—

Amino-acid sequence (132 residues)

MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL IIIPVLVVQA QR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards