Interleukin-1 receptor-like 1 (IL1RL1)

About Interleukin-1 receptor-like 1

Interleukin-1 receptor-like 1 (IL1RL1) is a protein from Homo sapiens identified by UniProt accession Q01638, 556 residues long. MolForge cross-references it against 0 known binders and 349 disease associations.

Target properties

Protein name	Interleukin-1 receptor-like 1
UniProt accession	Q01638
Gene	IL1RL1
Organism	Homo sapiens
Length	556 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (349)

Diseases linked to this target (Open Targets).

asthma · score 0.51
eosinophil count · score 0.50
Ascending aortic dissection · score 0.49
allergic rhinitis · score 0.49
interleukin 1 receptor-like 1 measurement · score 0.47
blood protein measurement · score 0.45
allergic disease · score 0.45
ST2 protein measurement · score 0.45
childhood onset asthma · score 0.44
Eczematoid dermatitis · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01638-F1	alphafold	PREDICTED	81.87	—

Amino-acid sequence (556 residues)

MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP LAAQKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards