Transcription factor AP-4 (TFAP4)

About Transcription factor AP-4

Transcription factor AP-4 (TFAP4) is a protein from Homo sapiens identified by UniProt accession Q01664, 338 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Transcription factor AP-4
UniProt accession	Q01664
Gene	TFAP4
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

Burkitts lymphoma · score 0.46
neurodegenerative disease · score 0.31
mean corpuscular volume · score 0.29
mean corpuscular hemoglobin concentration · score 0.27
mean corpuscular hemoglobin · score 0.25
platelet count · score 0.24
non-Hodgkins lymphoma · score 0.22
heel bone mineral density · score 0.21
mean reticulocyte volume · score 0.18
cortical surface area measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01664-F1	alphafold	PREDICTED	72.90	—

Amino-acid sequence (338 residues)

MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP PPPPSHHINV VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards