About DNA-binding protein SATB1
DNA-binding protein SATB1 (SATB1) is a protein
from Homo sapiens identified by UniProt accession
Q01826, 763 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | DNA-binding protein SATB1 |
|---|
| UniProt accession | Q01826 |
|---|
| Gene | SATB1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 763 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (289)
Diseases linked to this target (Open Targets).
- developmental delay with dysmorphic facies and dental anomalies · score 0.62
- Kohlschutter-Tonz syndrome-like · score 0.61
- genetic disorder · score 0.45
- Neurodevelopmental disorder · score 0.44
- Intellectual disability · score 0.37
- complex neurodevelopmental disorder · score 0.37
- diet measurement · score 0.35
- Neurodevelopmental delay · score 0.34
- body fat percentage · score 0.31
- platelet count · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01826-F1 | alphafold | PREDICTED | 65.27 | — |
Amino-acid sequence (763 residues)
MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGA KMQGVPLKHS GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD ATVADMLQDV YHVVTLKIQL HSCPKLEDLP PEQWSHTTVR NALKDLLKDM NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY KHFKKTKDMM VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP PPVSRSMNKP LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR TQGLLSEILR KEEDPKTASQ SLLVNLRAMQ NFLQLPEAER DRIYQDERER SLNAASAMGP APLISTPPSR PPQVKTATIA TERNGKPENN TMNINASIYD EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP ENRTLWENLS MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ QQQQQQQAPP PPQPQQQPQT GPRLPPRQPT VASPAESDEE NRQKTRPRTK ISVEALGILQ SFIQDVGLYP DEEAIQTLSA QLDLPKYTII KFFQNQRYYL KHHGKLKDNS GLEVDVAEYK EEELLKDLEE SVQDKNTNTL FSVKLEEELS VEGNTDINTD LKD
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