About RNA-binding protein EWS
RNA-binding protein EWS (EWSR1) is a protein
from Homo sapiens identified by UniProt accession
Q01844, 656 residues long.
MolForge cross-references it against 0 known binders and
443 disease associations.
Target properties
| Protein name | RNA-binding protein EWS |
|---|
| UniProt accession | Q01844 |
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| Gene | EWSR1 |
|---|
| Organism | Homo sapiens |
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| Length | 656 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (443)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- Ewing sarcoma · score 0.42
- desmoplastic small round cell tumor · score 0.38
- clear cell sarcoma · score 0.38
- myoepithelial tumor · score 0.38
- synovial sarcoma · score 0.38
- extraskeletal myxoid chondrosarcoma · score 0.38
- rhabdomyosarcoma · score 0.38
- Ewing sarcoma/peripheral primitive neuroectodermal tumor · score 0.37
- myxoid chondrosarcoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01844-F1 | alphafold | PREDICTED | 50.41 | — |
Amino-acid sequence (656 residues)
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE RRDRPY
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