Cerebellar degeneration-related protein 2 (CDR2)

About Cerebellar degeneration-related protein 2

Cerebellar degeneration-related protein 2 (CDR2) is a protein from Homo sapiens identified by UniProt accession Q01850, 454 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Cerebellar degeneration-related protein 2
UniProt accession	Q01850
Gene	CDR2
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
body height · score 0.23
body weight · score 0.13
neoplasm · score 0.08
systemic lupus erythematosus · score 0.05
bone density · score 0.04
urate measurement · score 0.04
paraneoplastic neurologic syndrome · score 0.03
mucocutaneous lymph node syndrome · score 0.03
cerebellar degeneration · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01850-F1	alphafold	PREDICTED	74.12	—

Amino-acid sequence (454 residues)

MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards