POU domain, class 4, transcription factor 1 (POU4F1)

About POU domain, class 4, transcription factor 1

POU domain, class 4, transcription factor 1 (POU4F1) is a protein from Homo sapiens identified by UniProt accession Q01851, 419 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	POU domain, class 4, transcription factor 1
UniProt accession	Q01851
Gene	POU4F1
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

ataxia, intention tremor, and hypotonia syndrome, childhood-onset · score 0.69
neurodegenerative disease · score 0.53
Non-progressive cerebellar ataxia with intellectual disability · score 0.40
mean reticulocyte volume · score 0.26
diastolic blood pressure · score 0.24
alcohol drinking · score 0.24
smoking status measurement · score 0.24
ovarian cancer · score 0.23
protein measurement · score 0.23
gastric adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01851-F1	alphafold	PREDICTED	60.74	—

Amino-acid sequence (419 residues)

MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI SSPSLALMAG AGGAGAAAGG GGAHDGPGGG GGPGGGGGPG GGPGGGGGGG PGGGGGGPGG GLLGGSAHPH PHMHSLGHLS HPAAAAAMNM PSGLPHPGLV AAAAHHGAAA AAAAAAAGQV AAASAAAAVV GAAGLASICD SDTDPRELEA FAERFKQRRI KLGVTQADVG SALANLKIPG VGSLSQSTIC RFESLTLSHN NMIALKPILQ AWLEEAEGAQ REKMNKPELF NGGEKKRKRT SIAAPEKRSL EAYFAVQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ KRMKFSATY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards