POU domain, class 5, transcription factor 1 (POU5F1)

About POU domain, class 5, transcription factor 1

POU domain, class 5, transcription factor 1 (POU5F1) is a protein from Homo sapiens identified by UniProt accession Q01860, 360 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	POU domain, class 5, transcription factor 1
UniProt accession	Q01860
Gene	POU5F1
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
gastric carcinoma · score 0.42
hidradenoma · score 0.37
myoepithelial tumor · score 0.37
lung carcinoma · score 0.37
cutaneous melanoma · score 0.31
lung adenocarcinoma · score 0.30
urinary bladder carcinoma · score 0.28
gastric adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q01860-F1	alphafold	PREDICTED	64.63	—

Amino-acid sequence (360 residues)

MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV TTLGSPMHSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards