About Tyrosine-protein kinase transmembrane receptor ROR2
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2) is a protein
from Homo sapiens identified by UniProt accession
Q01974, 943 residues long.
MolForge cross-references it against 0 known binders and
974 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase transmembrane receptor ROR2 |
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| UniProt accession | Q01974 |
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| Gene | ROR2 |
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| Organism | Homo sapiens |
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| Length | 943 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (974)
Diseases linked to this target (Open Targets).
- autosomal recessive Robinow syndrome · score 0.81
- brachydactyly type B1 · score 0.75
- neurodegenerative disease · score 0.50
- body height · score 0.41
- facial morphology measurement · score 0.39
- fetal akinesia deformation sequence 1 · score 0.34
- fetal akinesia deformation sequence · score 0.33
- arthrogryposis multiplex congenita · score 0.33
- Short stature · score 0.32
- sitting height measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q01974-F1 | alphafold | PREDICTED | 68.29 | — |
Amino-acid sequence (943 residues)
MARGSALPRR PLLCIPAVWA AAALLLSVSR TSGEVEVLDP NDPLGPLDGQ DGPIPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA PVVQEPRRII IRKTEYGSRL RIQDLDTTDT GYYQCVATNG MKTITATGVL FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD ARSRTPKPRE LCRDECEVLE SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC MRIGIPAERL GRYHQCYNGS GMDYRGTAST TKSGHQCQPW ALQHPHSHHL SSTDFPELGG GHAYCRNPGG QMEGPWCFTQ NKNVRMELCD VPSCSPRDSS KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ DMEMPLINQH KQAKLKEISL SAVRFMEELG EDRFGKVYKG HLFGPAPGEQ TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNVVCLL GVVTKDQPLS MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA AGMEYLSSHH VVHKDLATRN VLVYDKLNVK ISDLGLFREV YAADYYKLLG NSLLPIRWMA PEAIMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD VVEMIRNRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRAWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYVGPK QKAPPFPQPQ FIPMKGQIRP MVPPPQLYVP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSMADRAALL SEGADDTQNA PEDGAQSTVQ EAEEEEEGSV PETELLGDCD TLQVDEAQVQ LEA
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