Myocyte-specific enhancer factor 2B (MEF2B)

About Myocyte-specific enhancer factor 2B

Myocyte-specific enhancer factor 2B (MEF2B) is a protein from Homo sapiens identified by UniProt accession Q02080, 365 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Myocyte-specific enhancer factor 2B
UniProt accession	Q02080
Gene	MEF2B
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
diffuse large B-cell lymphoma · score 0.49
lymphoma · score 0.37
non-Hodgkins lymphoma · score 0.37
lysosomal storage disease · score 0.31
mean arterial pressure · score 0.27
diastolic blood pressure · score 0.27
obsessive-compulsive symptom measurement · score 0.24
total blood protein measurement · score 0.23
triglyceride measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02080-F1	alphafold	PREDICTED	60.77	—

Amino-acid sequence (365 residues)

MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS ANRLFQYAST DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL EPDEGPEEPG EKFRRLAGEG GDPALPRPRL YPAAPAMPSP DVVYGALPPP GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP GLVHPLFSPS HLTSKTPPPL YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT PGPPLGSFPF LPGGPPVGAE AWARRVPQPA APPRRPPQSA SSLSASLRPP GAPATFLRPS PIPCSSPGPW QSLCGLGPPC AGCPWPTAGP GRRSPGGTSP ERSPGTARAR GDPTSLQASS EKTQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards