About N-acylethanolamine-hydrolyzing acid amidase
N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a protein
from Homo sapiens identified by UniProt accession
Q02083, 359 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | N-acylethanolamine-hydrolyzing acid amidase |
|---|
| UniProt accession | Q02083 |
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| Gene | NAAA |
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| Organism | Homo sapiens |
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| Length | 359 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (147)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.31
- N-acylethanolamine-hydrolyzing acid amidase measurement · score 0.28
- cerebrospinal fluid biomarker measurement · score 0.21
- protein measurement · score 0.17
- Blackfan-Diamond anemia · score 0.07
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- microcytic anemia with liver iron overload · score 0.06
- Adult-onset autosomal recessive sideroblastic anemia · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02083-F1 | alphafold | PREDICTED | 92.25 | — |
Amino-acid sequence (359 residues)
MRTADREARP GLPSLLLLLL AGAGLSAASP PAAPRFNVSL DSVPELRWLP VLRHYDLDLV RAAMAQVIGD RVPKWVHVLI GKVVLELERF LPQPFTGEIR GMCDFMNLSL ADCLLVNLAY ESSVFCTSIV AQDSRGHIYH GRNLDYPFGN VLRKLTVDVQ FLKNGQIAFT GTTFIGYVGL WTGQSPHKFT VSGDERDKGW WWENAIAALF RRHIPVSWLI RATLSESENF EAAVGKLAKT PLIADVYYIV GGTSPREGVV ITRNRDGPAD IWPLDPLNGA WFRVETNYDH WKPAPKEDDR RTSAIKALNA TGQANLSLEA LFQILSVVPV YNNFTIYTTV MSAGSPDKYM TRIRNPSRK
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