About Guanylate cyclase soluble subunit alpha-1
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1) is a protein
from Homo sapiens identified by UniProt accession
Q02108, 690 residues long.
MolForge cross-references it against 0 known binders and
168 disease associations.
Target properties
| Protein name | Guanylate cyclase soluble subunit alpha-1 |
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| UniProt accession | Q02108 |
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| Gene | GUCY1A1 |
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| Organism | Homo sapiens |
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| Length | 690 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (168)
Diseases linked to this target (Open Targets).
- Moyamoya disease with early-onset achalasia · score 0.66
- cardiovascular disease · score 0.60
- pulmonary arterial hypertension · score 0.57
- diastolic blood pressure · score 0.55
- heart failure · score 0.54
- hypertension · score 0.53
- pulmonary hypertension · score 0.52
- systolic blood pressure · score 0.51
- coronary artery disease · score 0.51
- alcohol drinking · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02108-F1 | alphafold | PREDICTED | 77.45 | — |
Amino-acid sequence (690 residues)
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY QQGTNSKPCF QKKDVEDGNA NFLGKASGID
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