About Dihydroorotate dehydrogenase (quinone), mitochondrial
Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) is a protein
from Homo sapiens identified by UniProt accession
Q02127, 395 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| UniProt accession | Q02127 |
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| Gene | DHODH |
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| Organism | Homo sapiens |
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| Length | 395 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (258)
Diseases linked to this target (Open Targets).
- postaxial acrofacial dysostosis · score 0.82
- rheumatoid arthritis · score 0.60
- multiple sclerosis · score 0.58
- psoriatic arthritis · score 0.52
- immune system disease · score 0.46
- relapsing-remitting multiple sclerosis · score 0.44
- juvenile idiopathic arthritis · score 0.37
- low density lipoprotein cholesterol measurement · score 0.34
- total cholesterol measurement · score 0.34
- COVID-19 · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02127-F1 | alphafold | PREDICTED | 96.11 | — |
Amino-acid sequence (395 residues)
MAWRHLKKRA QDAVIILGGG GLLFASYLMA TGDERFYAEH LMPTLQGLLD PESAHRLAVR FTSLGLLPRA RFQDSDMLEV RVLGHKFRNP VGIAAGFDKH GEAVDGLYKM GFGFVEIGSV TPKPQEGNPR PRVFRLPEDQ AVINRYGFNS HGLSVVEHRL RARQQKQAKL TEDGLPLGVN LGKNKTSVDA AEDYAEGVRV LGPLADYLVV NVSSPNTAGL RSLQGKAELR RLLTKVLQER DGLRRVHRPA VLVKIAPDLT SQDKEDIASV VKELGIDGLI VTNTTVSRPA GLQGALRSET GGLSGKPLRD LSTQTIREMY ALTQGRVPII GVGGVSSGQD ALEKIRAGAS LVQLYTALTF WGPPVVGKVK RELEALLKEQ GFGGVTDAIG ADHRR
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