About Guanylate cyclase soluble subunit beta-1
Guanylate cyclase soluble subunit beta-1 (GUCY1B1) is a protein
from Homo sapiens identified by UniProt accession
Q02153, 619 residues long.
MolForge cross-references it against 0 known binders and
215 disease associations.
Target properties
| Protein name | Guanylate cyclase soluble subunit beta-1 |
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| UniProt accession | Q02153 |
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| Gene | GUCY1B1 |
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| Organism | Homo sapiens |
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| Length | 619 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (215)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.70
- angina pectoris · score 0.63
- hypertension · score 0.62
- myocardial infarction · score 0.61
- cardiovascular disease · score 0.60
- pulmonary arterial hypertension · score 0.58
- heart failure · score 0.57
- pulmonary hypertension · score 0.55
- hemorrhage · score 0.54
- congestive heart failure · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02153-F1 | alphafold | PREDICTED | 85.39 | — |
Amino-acid sequence (619 residues)
MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE GLQDIVIGII KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE NGTQESRISP YTFCKAFPFH IIFDRDLVVT QCGNAIYRVL PQLQPGNCSL LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGTE ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR DLVLLGEQFR EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP SVANELRHKR PVPAKRYDNV TILFSGIVGF NAFCSKHASG EGAMKIVNLL NDLYTRFDTL TDSRKNPFVY KVETVGDKYM TVSGLPEPCI HHARSICHLA LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY CLFGNTVNLT SRTETTGEKG KINVSEYTYR CLMSPENSDP QFHLEHRGPV SMKGKKEPMQ VWFLSRKNTG TEETKQDDD
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