Cytochrome c oxidase subunit 6A2, mitochondrial…

About Cytochrome c oxidase subunit 6A2, mitochondrial

Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) is a protein from Homo sapiens identified by UniProt accession Q02221, 97 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Cytochrome c oxidase subunit 6A2, mitochondrial
UniProt accession	Q02221
Gene	COX6A2
Organism	Homo sapiens
Length	97 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

mitochondrial complex 4 deficiency, nuclear type 18 · score 0.69
Isolated cytochrome C oxidase deficiency · score 0.37
Parkinson disease · score 0.32
lysosomal storage disease · score 0.32
neurodegenerative disease · score 0.32
Alzheimer disease · score 0.32
multiple sclerosis · score 0.32
Glycosuria · score 0.09
Red cell distribution width · score 0.08
mean platelet volume · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q02221-F1	alphafold	PREDICTED	85.68	—

Amino-acid sequence (97 residues)

MALPLRPLTR GLASAAKGGH GGAGARTWRL LTFVLALPSV ALCTFNSYLH SGHRPRPEFR PYQHLRIRTK PYPWGDGNHT LFHNSHVNPL PTGYEHP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)