About Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) is a protein
from Homo sapiens identified by UniProt accession
Q02252, 535 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial |
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| UniProt accession | Q02252 |
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| Gene | ALDH6A1 |
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| Organism | Homo sapiens |
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| Length | 535 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- methylmalonate semialdehyde dehydrogenase deficiency · score 0.74
- Developmental delay due to methylmalonate semialdehyde dehydrogenase deficiency · score 0.66
- genetic disorder · score 0.41
- Red cell distribution width · score 0.35
- erythrocyte count · score 0.21
- blood protein measurement · score 0.19
- mean corpuscular hemoglobin concentration · score 0.18
- mean corpuscular volume · score 0.17
- mean corpuscular hemoglobin · score 0.16
- chronotype measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02252-F1 | alphafold | PREDICTED | 93.74 | — |
Amino-acid sequence (535 residues)
MAALLAAAAV RARILQVSSK VKSSPTWYSA SSFSSSVPTV KLFIGGKFVE SKSDKWIDIH NPATNEVIGR VPQATKAEMD AAIASCKRAF PAWADTSVLS RQQVLLRYQQ LIKENLKEIA KLITLEQGKT LADAEGDVFR GLQVVEHACS VTSLMMGETM PSITKDMDLY SYRLPLGVCA GIAPFNFPAM IPLWMFPMAM VCGNTFLMKP SERVPGATML LAKLLQDSGA PDGTLNIIHG QHEAVNFICD HPDIKAISFV GSNKAGEYIF ERGSRHGKRV QANMGAKNHG VVMPDANKEN TLNQLVGAAF GAAGQRCMAL STAVLVGEAK KWLPELVEHA KNLRVNAGDQ PGADLGPLIT PQAKERVCNL IDSGTKEGAS ILLDGRKIKV KGYENGNFVG PTIISNVKPN MTCYKEEIFG PVLVVLETET LDEAIQIVNN NPYGNGTAIF TTNGATARKY AHLVDVGQVG VNVPIPVPLP MFSFTGSRSS FRGDTNFYGK QGIQFYTQLK TITSQWKEED ATLSSPAVVM PTMGR
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