About Pro-neuregulin-1, membrane-bound isoform
Pro-neuregulin-1, membrane-bound isoform (NRG1) is a protein
from Homo sapiens identified by UniProt accession
Q02297, 640 residues long.
MolForge cross-references it against 0 known binders and
516 disease associations.
Target properties
| Protein name | Pro-neuregulin-1, membrane-bound isoform |
|---|
| UniProt accession | Q02297 |
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| Gene | NRG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 640 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (516)
Diseases linked to this target (Open Targets).
- cancer · score 0.59
- lung adenocarcinoma · score 0.53
- thyroid carcinoma · score 0.47
- non-small cell lung carcinoma · score 0.47
- urate measurement · score 0.42
- chronotype measurement · score 0.41
- hemoglobin measurement · score 0.41
- creatinine measurement · score 0.41
- hematocrit · score 0.40
- body mass index · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02297-F1 | alphafold | PREDICTED | 56.66 | — |
Amino-acid sequence (640 residues)
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV
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