About Sterol 26-hydroxylase, mitochondrial
Sterol 26-hydroxylase, mitochondrial (CYP27A1) is a protein
from Homo sapiens identified by UniProt accession
Q02318, 531 residues long.
MolForge cross-references it against 0 known binders and
496 disease associations.
Target properties
| Protein name | Sterol 26-hydroxylase, mitochondrial |
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| UniProt accession | Q02318 |
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| Gene | CYP27A1 |
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| Organism | Homo sapiens |
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| Length | 531 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (496)
Diseases linked to this target (Open Targets).
- cerebrotendinous xanthomatosis · score 0.87
- Abnormality of the cardiovascular system · score 0.51
- triglyceride measurement · score 0.27
- serum urea measurement · score 0.26
- Seizure · score 0.18
- photosensitive epilepsy · score 0.18
- glioblastoma multiforme · score 0.17
- Intellectual disability · score 0.16
- reticulocyte count · score 0.15
- body mass index · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02318-F1 | alphafold | PREDICTED | 88.02 | — |
Amino-acid sequence (531 residues)
MAALGCARLR WALRGAGRGL CPHGARAKAA IPAALPSDKA TGAPGAGPGV RRRQRSLEEI PRLGQLRFFF QLFVQGYALQ LHQLQVLYKA KYGPMWMSYL GPQMHVNLAS APLLEQVMRQ EGKYPVRNDM ELWKEHRDQH DLTYGPFTTE GHHWYQLRQA LNQRLLKPAE AALYTDAFNE VIDDFMTRLD QLRAESASGN QVSDMAQLFY YFALEAICYI LFEKRIGCLQ RSIPEDTVTF VRSIGLMFQN SLYATFLPKW TRPVLPFWKR YLDGWNAIFS FGKKLIDEKL EDMEAQLQAA GPDGIQVSGY LHFLLASGQL SPREAMGSLP ELLMAGVDTT SNTLTWALYH LSKDPEIQEA LHEEVVGVVP AGQVPQHKDF AHMPLLKAVL KETLRLYPVV PTNSRIIEKE IEVDGFLFPK NTQFVFCHYV VSRDPTAFSE PESFQPHRWL RNSQPATPRI QHPFGSVPFG YGVRACLGRR IAELEMQLLL ARLIQKYKVV LAPETGELKS VARIVLVPNK KVGLQFLQRQ C
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