About D-beta-hydroxybutyrate dehydrogenase, mitochondrial
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) is a protein
from Homo sapiens identified by UniProt accession
Q02338, 343 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | D-beta-hydroxybutyrate dehydrogenase, mitochondrial |
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| UniProt accession | Q02338 |
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| Gene | BDH1 |
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| Organism | Homo sapiens |
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| Length | 343 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.26
- visual perception measurement · score 0.25
- anemia (phenotype) · score 0.25
- bone density · score 0.08
- urate measurement · score 0.08
- acute myeloid leukemia · score 0.08
- lung adenocarcinoma · score 0.07
- neoplasm · score 0.06
- lymph node metastatic carcinoma · score 0.04
- diabetic nephropathy · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q02338-F1 | alphafold | PREDICTED | 86.86 | — |
Amino-acid sequence (343 residues)
MLATRLSRPL SRLPGKTLSA CDRENGARRP LLLGSTSFIP IGRRTYASAA EPVGSKAVLV TGCDSGFGFS LAKHLHSKGF LVFAGCLMKD KGHDGVKELD SLNSDRLRTV QLNVCSSEEV EKVVEIVRSS LKDPEKGMWG LVNNAGISTF GEVEFTSLET YKQVAEVNLW GTVRMTKSFL PLIRRAKGRV VNISSMLGRM ANPARSPYCI TKFGVEAFSD CLRYEMYPLG VKVSVVEPGN FIAATSLYSP ESIQAIAKKM WEELPEVVRK DYGKKYFDEK IAKMETYCSS GSTDTSPVID AVTHALTATT PYTRYHPMDY YWWLRMQIMT HLPGAISDMI YIR
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